FE 203799

FE 203799 is a peptide analogue of GLP-2 and acts as a full agonist at the GLP-2 receptor in vitro with high potency and selectivity comparable to native GLP-2. FE 203799 is resistant to cleavage by DPP4 and has very low clearance and a sustained half-life in circulation in vivo compared to native GLP-2. The pharmacokinetics of FE 203799 may enable once or twice weekly dosing to achieve efficacy in humans.